OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion of RAD1 has no effect on life span (Park et al., 1999).
Gene FunctionFunctions in complex with RAD10 (Tomkinson et al., 1994). Required for repair of double-strand DNA breaks by single-strand annealing (Ivanov and Haber, 1995) and for UV-excision repair (Wang et al., 1993).
Other PhenotypesSensitive to UV-induced DNA damage (Kadyk and Hartwell, 1993).
HomologsS.p. rad16
C.e. C47D12.8
D.m. MEI-9
M.m. ERCC4
H.s. ERCC4
Primary ReferencePark, P. U., Defossez, P. A., and Guarente, L. (1999). Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol Cell Biol 19, 3848-56. [Abstract]
Other ReferencesIvanov, E. L., and Haber, J. E. (1995). RAD1 and RAD10, but not other excision repair genes, are required for double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol 15, 2245-51. [Abstract]
Kadyk, L. C., and Hartwell, L. H. (1993). Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae. Genetics 133, 469-87. [Abstract]
Tomkinson, A. E., Bardwell, A. J., Tappe, N., Ramos, W., and Friedberg, E. C. (1994). Purification of Rad1 protein from Saccharomyces cerevisiae and further characterization of the Rad1/Rad10 endonuclease complex. Biochemistry 33, 5305-11. [Abstract]
Wang, Z., Wu, X., and Friedberg, E. C. (1993). Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 90, 4907-11. [Abstract]
Relevant LinksSGD:
Keywordshomologous recombination, DNA repair, rDNA, DNA damage, yeast, replicative senescence, Saccharomyces, cerevisiae