OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeNo effect on life-span
Allele TypeDeletion
DescriptionDeletion of QPT1 has no effect on life span (Lin et al., 2000). QPT1 is not required for life span extension by caloric restriction.
Gene FunctionPutative quinolinic acid phosphoribosyltransferase. Involved in tryptophan degradation and NAD biosynthesis.
Other PhenotypesMutation of QPT1 is synthetically lethal with mutation of NPT1 (Lin et al., 2000).
HomologsH.s. QPRT
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesNone
Relevant LinksYPD:
Keywordsmetabolism, replicative senescence, Saccharomyces, cerevisiae, yeast