NamePKB
OrganismDrosophila melanogaster
Aging PhenotypeShortened life-span
Allele TypeRecessive
StrainUnknown
DescriptionPKB homozygotes have a significantly decreased life span (Clancy et al., 2001).
Gene FunctionProtein kinase B. age-1 homolog.
Other PhenotypesHeterozygous animals form dwarfs (Clancy et al., 2001).
HomologsN/A
Primary ReferenceClancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., and Partridge, L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104-6. [Abstract]
Other ReferencesNone.
Relevant LinksFlyBase: http://flybase.bio.indiana.edu/.bin/fbidq.html?FBgn0010379
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=41957
KeywordsDrosophila, melanogaster, fly, insulin, signaling