NamePit1
OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeRecessive
Strain(C3H/HeJ x DW/J)F1
DescriptionHomozygous Pit1 dw/dw animals show a 42% increase in mean life span (Flurkey et al., 2001). Mutant mice also show delays in age-dependent collagen cross-linking and age-dependent indices of immune system status (Flurkey et al., 2001).
Gene FunctionPituitary specific transcription factor.
Other PhenotypesPit1 is required for normal development of the anterior pituitary. Activation of the Prop1 pathway is required for Pit1 expression (Gage et al., 1996; Sornson et al., 1996).
HomologsR.n. Pou1F1
H.s. POU1F1
Primary ReferenceFlurkey, K., Papaconstantinou, J., Miller, R. A., and Harrison, D. E. (2001). Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A 98, 6736-6741. [Abstract]
Other ReferencesGage, P. J., Brinkmeier, M. L., Scarlett, L. M., Knapp, L. T., Camper, S. A., and Mahon, K. A. (1996). The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell prolife [Abstract]
Sornson, M. W., Wu, W., Dasen, J. S., Flynn, S. E., Norman, D. J., O'Connell, S. M., Gukovsky, I., Carriere, C., Ryan, A. K., Miller, A. P., Zuo, L., Gleiberman, A. S., Andersen, B., Beamer, W. G., and Rosenfeld, M. G. (1996). Pituitary lineage determina [Abstract]
Relevant LinksJAX: http://www.informatics.jax.org/searches/mlc.cgi?12342
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=18736
KeywordsM. musculus, mouse, growth hormone