InterventionCaloric restriction
Alternate Name
OrganismRattus norvegicus
Aging PhenotypeLife-span extension
Allele TypeN/A
StrainFischer 344, Wistar
DescriptionCaloric restriction extends life spans in rats (McCay et al., 1935). Caloric restriction of 30-60% results in an increase in both mean and maximum life span (reviewed in Weindruch and Sohal, 1997; Masoro, 2000).
Gene FunctionN/A
Other PhenotypesCalorically restricted rats have fewer age-associated diseases.
Primary ReferenceMcCay, C. M., Crowell, M. F., and Maynard, L. A. (1935). The effect of retarded growth upon the length of life and upon ultimate size. J Nutr 10, 63-79.
Other ReferencesMasoro, E. J. (2000). Caloric restriction and aging: an update. Exp Gerontol 35, 299-305. [Abstract]
Weindruch, R., and Sohal, R. S. (1997). Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging. N Engl J Med 337, 986-94. [Abstract]
Relevant LinksNone
KeywordsR. norvegicus, caloric restriction, metabolism, dietary restriction, calorie restriction