Namepdk-1
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function alleles extend life span by 60% (Paradis et al., 1999).
Gene FunctionSerine/threonine kinase. Required to prevent dauer arrest (Paradis et al., 1999).
Other PhenotypesMutants are dauer constitutive and a gain of function allele can suppress age-1 dauer constitutive phenotype (Paradis et al., 1999). Dauer constitutive phenotype of pdk-1(sa680) is suppressed by daf-16 (Paradis et al. 1999)
HomologsS.c. PKH2, PKH1, YDR466W, YPK2, YPK1, TPK3 ...
S.p. ksg1, Spbc4C3.11, Spcc24B10.07, Spbc1861.09, pka1, pck2 ...
C.e. W04B5.5, kin-13, kin-11, akt-1, akt-2, W10G6.2 ...
D.m. Pk61C, CG1201, Pkc98E, inaC, CG6622, Pkc53E ...
R.n. Rn.10905, Rn.10506, Akt2, Rn.10398, Akt, Prkcb1 ...
M.m. Pdpk1, Akt3, Pkce, Akt2, Pkch, Pkc1 ...
H.s. PDPK1, PKBG, PRKCE, PRKCA, AKT2, PRKCB1 ...
Primary ReferenceParadis, S., Ailion, M., Toker, A., Thomas, J. H., and Ruvkun, G. (1999). A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev 13, 1438-52. [Abstract]
Other ReferencesNone.
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=pdk-1
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=180475
KeywordsCaenorhabditis, elegans, worm, dauer, insulin, signaling