NamePDE2
OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
StrainPSY316
DescriptionDeletion shortens lifespan to 75% of wild-type (Lin et al., 2000).
Gene FunctionPhosophodiesterase that catalyzes the hydrolysis of cAMP (Wilson and Tatchell, 1988).
Other PhenotypesNull mutant sensitive to oxidative stress (Charizanis et al., 1999).
HomologsC.e. Y95B8A.10, R153.1
D.m. DNC, CG5411, CG14940
M.m. DE4B, PDE9A, PDE4A
H.s. PDE9A, PDE4B, PDE4D
Primary ReferenceLin, S. J., Defossez, P. A., and Guarente, L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126-8. [Abstract]
Other ReferencesWilson, R. B., and Tatchell, K. (1988). SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae. Mol Cell Biol 8, 505-10. [Abstract]
Charizanis, C., Juhnke, H., Krems, B., and Entian, K. D. (1999). The oxidative stress response mediated via Pos9/Skn7 is negatively regulated by the Ras/PKA pathway in Saccharomyces cerevisiae. Mol Gen Genet 261, 740-52. [Abstract]
Relevant LinksSGD: http://genome-www4.stanford.edu/cgi-bin/SGD/locus.pl?locus=pde2
YPD: http://www.proteome.com/databases/YPD/reports/PDE2.html
Keywordscaloric restriction, metabolism, signaling, cell cycle, oxidative stress, yeast, replicative senescence, Saccharomyces, cerevisiae