OrganismMus musculus
Aging PhenotypeLife-span extension
Allele TypeDeletion
DescriptionMice mutant for p66shc have increased life span as follows:
p66shc +/+ mice: 761 days
p66shc +/- mice: 815 days
p66shc -/- mice: 973 days
(Migliaccio et al, 1999).
Gene FunctionThe p66shc gene encodes an alternative splicing variant of signaling adaptor Shc, which is involved in EGF receptor signaling in the mitogen activated protein kinase pathway (Migliaccio et al, 1999).
Other Phenotypesp66shc -/- cells are more resistant to apoptosis induced by hydrogen peroxide and UV light (Migliaccio et al., 1999). p66shc -/- mice are more resistant to oxidative stress induced by paraquat (Migliaccio et al., 1999).
HomologsH. s. p66shc
R.n. shc transforming protein
Gallus gallus - adaptor protein SHC
Primary ReferenceMigliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., and Pelicci, P. G. (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402, 309-13. [Abstract]
Other ReferencesNone
Relevant LinksJAX:
KeywordsM. musculus, mouse, oxidative stress, signaling