OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionLoss of function mutation increases life span up t 0 40% (Apfeld and Kenyon, 1999).
Gene FunctionRequired for dauer formation and recovery (Vowels and Thomas, 1992; Malone et al., 1996).
Other PhenotypesIn addition to being dauer defective, loss of function mutants are chemotaxis defective (Culotti and Russell, 1978; Bargmann et al., 1993). and dye filling defective (Collet et al., 1998). They have extremely shortened axonemes, ectopic assembly of ciliary structures and microtubules in many sensory neurons (Perkins et al., 1986).
HomologsD.m. CG9595
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesBargmann, C. I., Hartwieg, E., and Horvitz, H. R. (1993). Odorant-selective genes and neurons mediate olfaction in C. elegans. Cell 74, 515-27. [Abstract]
Collet, J., Spike, C. A., Lundquist, E. A., Shaw, J. E., and Herman, R. K. (1998). Analysis of osm-6, a gene that affects sensory cilium structure and sensory neuron function in Caenorhabditis elegans. Genetics 148, 187-200. [Abstract]
Culotti, J. G., and Russell, R. L. (1978). Osmotic avoidance defective mutants of the nematode Caenorhabditis elegans. Genetics 90, 243-56. [Abstract]
Malone, E. A., Inoue, T., and Thomas, J. H. (1996). Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143, 1193-205. [Abstract]
Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Relevant LinksWormBase:;class=Locus
KeywordsCaenorhabditis, elegans, worm, neurons, dauer