Nameosm-3
OrganismCaenorhabditis elegans
Aging PhenotypeLife-span extension
Allele TypeRecessive
StrainBristol N2
DescriptionRecessive loss of function alleles can extend life span 100%. Life span extension suppressed by gonad ablation but not germ line ablation (Apfeld and Kenyon, 1999).
Gene FunctionKinesin motor domain. Required for dauer formation (Vowels and Thomas, 1992), and mediates osmotic aviodance and chemotaxis (Tabish et al., 1995).
Other PhenotypesMutants do not form dauers in response to starvation (Vowels and Thomas, 1992). Mutants have defective cilia (Vowels and Thomas, 1992) and are defective in chemosensory response and chemotaxis (Tabish et al., 1995).
HomologsS.c. KIP3, KIP1, KAR3, CIN8, KIP2, SMY1
S.p. klp3, cut7, klp5, klp6, pkl1, Spac664.10, tea2, klp8, klp1
C.e. krp85, klp-11, klp-12, klp-14, unc-116, unc-104 ...
D.m. Klp64D, Klp68D, Khc-73, Klp61F, Khc, Klp3A ...
R.n. Rn.10894, Rn.21641
M.m. Kif3a, Kif3b, Kif3c, Kif4, Kif1a, Kif21b ...
H.s. KIF3B, KIF3A, KIF3C, KIF4, ATSV, KIF5B ...
Primary ReferenceApfeld, J., and Kenyon, C. (1999). Regulation of lifespan by sensory perception in Caenorhabditis elegans. Nature 402, 804-9. [Abstract]
Other ReferencesTabish, M., Siddiqui, Z. K., Nishikawa, K., and Siddiqui, S. S. (1995). Exclusive expression of C. elegans osm-3 kinesin gene in chemosensory neurons open to the external environment. J Mol Biol 247, 377-89. [Abstract]
Vowels, J. J., and Thomas, J. H. (1992). Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130, 105-23. [Abstract]
Relevant LinksWormBase: http://www.wormbase.org/perl/ace/elegans/gene/locus?name=osm-3
LocusLink: http://www.ncbi.nih.gov/LocusLink/LocRpt.cgi?l=177141
KeywordsCaenorhabditis, elegans, worm, neurons, dauer