InterventionCaloric restriction
Alternate Name
OrganismMacaca mulatta
Aging PhenotypeN/A
Allele TypeN/A
StrainMacaca mulatta
DescriptionCaloric restriction (to 60-80% of ad lib levels) increases mean and maximum life span of laboratory rodents (eg Weindruch and Walfor, 1988). A study on rhesus monkeys was begun at the National Institute on Aging in 1987 to study the effects of caloric restriction (by 30%). There were three groups at the beginning of the study: juvenile, adolescent, and old (Ingram et al, 1990). Another study of adult-onset caloric restriction was begun in 1989 at the University of Wisconsin, Madison (Kemnitz et al, 1993). The results, on aging, are still pending.
Gene FunctionN/A
Other PhenotypesRhesus monkeys on caloric restriction have lower body temperature, fasting blood glucose and insulin, and serum triglycerides and cholesterol (Lane et al, 1999). They are more sensitive to insulin than ad lib fed controls and have increased HDL2B (Lane et al, 1999). They have reduced body fat and lower blood pressure (Lane et al, 1999).
Primary ReferenceIngram DK, Cutler RG, Weindruch R, Renquist DM, Knapka JJ, April M, Belcher CT, Clark MA, Hatcherson CD, Marriott BM, et al. (1990) Dietary restriction and aging: the initiation of a primate study. J Gerontol. 45, B148-63. [Abstract]
Other ReferencesKemnitz JW, Weindruch R, Roecker EB, Crawford K, Kaufman PL, Ershler WB. (1993) Dietary restriction of adult male rhesus monkeys: design, methodology, and preliminary findings from the first year of study. J Gerontol. 48, 17-26. [Abstract]
Lane MA, Ingram DK, Roth GS. (1999) Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk. Toxicol Sci. 52(2 Suppl):41-8. [Abstract]
Weindruch, R. H., and Walford, R. L. (1988). The Retardation of Aging and Disease by Dietary Restriction. (Springfield, IL.: Thomas).
Relevant LinksNone
KeywordsMacaca, mulatta, monkey, primate, caloric restriction, metabolism, insulin, dietary restriction, calorie restriction