OrganismSaccharomyces cerevisiae (replicative)
Aging PhenotypeShortened life-span
Allele TypeDeletion
DescriptionDeletion of ADA1 shortens life-span by approximately 80% (Sinclair et al., 1997). This is not a premature aging phenotype as “old” ADA1 cells do not become prematurely sterile or show other biomarkers of yeast aging (Sinclair et al., 1997; Smeal et al., 1996).
Gene FunctionTranscription factor in ADA complex.
Other PhenotypesADA1 mutants are temperature-sensitive and respiratory-deficient (Marcus et al., 1994).
HomologsS.p. Spbc887.18c
Primary ReferenceSinclair, D. A., Mills, K., and Guarente, L. (1997). Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277, 1313-6. [Abstract]
Other ReferencesMarcus, G. A., Silverman, N., Berger, S. L., Horiuchi, J., and Guarente, L. (1994). Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. Embo J 13, 4807-15. [Abstract]
Smeal, T., Claus, J., Kennedy, B., Cole, F., and Guarente, L. (1996). Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84, 633-42. [Abstract]
Relevant LinksSGD:
Keywordssterility, transcription factor, replicative senescence, Saccharomyces, cerevisiae, yeast